布地奈德混悬液对慢性鼻-鼻窦炎鼻内镜术后窦腔黏膜上皮化的作用

目的观察布地奈德对慢性鼻-鼻窦炎病人行鼻内镜手术后窦腔黏膜上皮化的作用。方法176例慢性鼻-鼻窦炎病人随机分为2组,治疗组82例,对照组94例。治疗组在术中及术后wk 1及wk 2复查时术腔加用布地奈德明胶海绵贴铺。除此之外,其他治疗均与对照组相同。术后复查6 mo以上,鼻内镜下观察术腔上皮化情况。结果治疗组上皮化时间为(5.7±s 1.1)wk,对照组为(7.4±1.6)wk,差异非常显著(P<0.01)。半年内治疗组81例上皮化,对照组85例上皮化,差异有显著意义(P<0.05)。结论术后局部应用布地奈德,能明显促进窦腔黏膜上皮化,缩短疗程。

Local application of budesonide for sinusoid mucosal epitheliosis of chronic rhino-sinusitis after endoscopic surgery

AIM To evaluate the role of budesonide locally applied for sinusoid mucosal epitheliosis of chronic rhino-sinusitis after endoscopic surgery.METHODS A total of 176 patients with chronic rhino-sinusitis were randomly divided into treatment group(n=82)and control group(n=94).The patients in treatment group were locally applied with budesonide gelfoam adhesives during and wk 1,wk 2 after the surgery.;the other therapies were the same as those of the control group.The re-epitheliosis of nasal mucosa was observed under nasal endoscopy during a follow-up over six months.RESULTS The average time of re-epitheliosis in the treatment group was(5.7±s 1.1)wk,vs(7.4±1.6)wk in control group,with significant statistical difference between the two groups(P<0.01).Six months follow up revealed 81/82 and 85/94 re-epitheliosis in treatment group and control group,respectively,showing obvious difference(P<0.05).CONCLUSION Budesonide locally applied in chronic rhino-sinusitis after endoscopic surgery can apparently promote re- epitheliosis and shorten the treatment course.