Effects of a single dose of cortisol on the neural correlates of episodic memory and error processing in healthy volunteers |
| |
Authors: | Hsu F C Garside M J Massey A E McAllister-Williams R H |
| |
Institution: | (1) Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK,;(2) , Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK, |
| |
Abstract: | Rationale. Neuropsychological impairments seen in depression may be secondary to hypercortisolaemia. Repeated cortisol administration
impairs episodic memory with an alteration in event-related potentials (ERPs) recorded during information retrieval. It is
unclear whether such ERP effects are specific to episodic memory, or whether repeated cortisol administration is required.
Objective. To investigate the effect of a single dose of hydrocortisone on the neural correlates of episodic memory and error detection.
Methods. Twenty healthy subjects were treated with hydrocortisone (100 mg) or placebo orally, in a double-blind, two-way crossover
study. ERPs were recorded during an episodic memory and a Stroop task, 1–3 h following the medication.
Results. Cortisol increased error rates during the Stroop task but had no effect on episodic memory. The magnitude of ERPs associated
with incorrect response in the Stroop task between −250 ms and +500 ms post-response was increased by cortisol, with no effect
on correct-response ERPs. There was no effect of cortisol on episodic memory-retrieval-dependent ERPs.
Conclusions. Cortisol can impair not only episodic memory but also processes involved in error detection. In contrast to repeated cortisol
administration, a single dose of cortisol does not alter the behavioural performance or the electrophysiological correlates
of episodic memory. However, it increases error rates in a choice response task with associated quantitative changes in incorrect-response
ERPs. This probably reflects an alteration in anterior cingulate cortex activity. Such changes may contribute to the neuropsychological
impairment seen in depression. This study also demonstrates the utility of ERPs for investigating the effect of neuroendocrine
manipulations on the neural correlates of neuropsychological function.
Electronic Publication |
| |
Keywords: | Hydrocortisone Event-related potentials Error processing Error negativity Human |
本文献已被 PubMed SpringerLink 等数据库收录! |
|