某院496例药品不良反应报告的趋势分析

目的研究我院药品不良反应（ADR）报告,分析其发生趋势,为临床合理用药提供对策。方法采取回顾性研究方法,针对我院2010年1月~2012年12月收集的496例ADR报告,分别从患者性别、年龄、药品种类、给药途径、累及器官系统以及临床表现等方面进行统计、分析。结果496例ADR报告中,60岁以上患者发生ADR的比例最高;最易引起ADR的药物为心血管系统用药,占41.53%;静脉滴注引发的ADR最多,占74.96%;皮肤及附件损害最为常见,占48.39%。结论医疗机构应加强ADR监测,充分发挥临床药师用药监护作用,合理用药,减少或避免ADR的发生。

Analysis of 496 Cases of Adverse Drug Reaction Reports in a Hospital

Objective To explore the occurrence trend of adverse drug reactions （ADRs） in a certain hospital in order to provide reference for the clinical rational use of drugs. Methods Totally 496 cases of ADR reports collected from Jan. 2010 to Dec. 2012 were analyzed retrospectively in respect of patient gender, age, drug categories, routes of administration, involved organs or systems and clinical manifestations, etc. Results In the 496 ADR cases, 41.53% were induced by cardiovascular drugs which had the highest tendency to induce ADRs; the largest proportion of the cases （74.96%） were induced by intravenous infusion; 48.39% were manifested as lesion of skin and its appendants, which was the most common ADR. The ADRs were most often seen in patients aged over 60 years. Conclusion Attention should be paid to strengthening ADR monitoring, making full use of clinical physicians in supervision of medication and rational use of drugs in order to reduce or avoid the occurrence of ADRs.