脑损伤恢复期神经内分泌改变及临床意义

目的探讨脑损伤恢复期神经内分泌激素异常的发生率及其临床意义。方法用放射免疫法测定患者脑损伤后3,6,12月周围静脉血中FT3、FT4、TSH、ACTH、GH、Cor、PRL、T、E2、P、FSH、LH的浓度,统计分析脑损伤恢复期神经内分泌激素异常的发生率及其与病情严重程度及恢复时间的关系。结果激素异常发生率和损伤严重程度呈正相关,损伤越重,激素异常发生率越高,差异有统计学意义(P0.05)。激素异常发生率随着时间的推移逐渐降低,3个月时为17.6%,6个月为16.2%,12个月为15.4%。但差异无统计学意义(P0.05)。结论颅脑损伤恢复期神经内分泌激素水平异常有一定的发生率,损伤越重,激素异常率越高,随着恢复时间的延长有下降趋势,可作为恢复期一项重要的检测指标,用于指导临床治疗。

Neuroendocrine hormone changes and their clinical significance in recovery phase of brain injury

Objective To study the incidence of neuroendocrine hormone abnormalities and its clinical significance in the recoveryphase of brain injury. Methods Patients with brain injury were included in this study. The concentrations of FT3, FT4, TSH,ACTH, GH, Cor, PRL, T, E2, P, FSH, and LH in the peripheral venous blood were measured by radioimmunoassay at 3, 6, and 12months after brain injury. Statistical analysis was performed to determine the incidence of neuroendocrine hormone abnormalities in therecovery phase of brain injury and its relationship with the disease severity and recovery time. Results The incidence of neuroendocrine hormone abnormalities was positively correlated with the severity of brain injury （P 〈 0.05 ）. The incidence of neuroendocrinehormone abnormalities was 17.6% , 16.2% , and 15.4% at 3, 6, and 12 months, respectively, after brain injury ; the incidence gradually decreased with time, but without significant differences between the values at the three time points （P 〉 0.05）. Conclusions Inthe recovery phase of brain injury, neuroendocrine hormone abnormalities may occur. The severer the brain injury, the higher the incidence of neuroendocrine hormone abnormalities ; the incidence of neuroendocrine hormone abnormalities gradually decreases with time.Neuroendocrine hormone levels can be used as an important index to guide clinical therapy.