抗结核分枝杆菌持留菌的药物研究进展

持留态结核分枝杆菌具有对现有抗结核药物表型耐药的特征,是结核病病程迁延和复发的主要原因.因此,研发抗结核分枝杆菌持留菌的药物,对缩短抗结核治疗疗程,减少耐药性发生意义重大.本文就结核分枝杆菌持留菌的耐药机制、PA-824等新药的研究进展以及筛选评价模型进行简要综述,为抗结核分枝杆菌持留菌药物的研究提供参考.

Studies on Anti-tuberculosis Persisters Agents

Persistent bacteria have the characteristic of phenotypic resistance to the antimycobacterial drugs. The presence of such persistent bacteria is considered to be the major cause for lengthy therapy and relapse of tuberculosis. There is an urgent need and significant interest in developing new drugs that target the persistent bacteria to shorten the therapy and reduce the drug resistance. This review on the resistant mechanism of persisters, recent developments on antipersister drugs such as PA-824 and the models for evaluating new drugs will provide references to the studies on TB drug discovery.