Inflammation-induced increase in the density of neuropeptide-immunoreactive nerve endings in rat skeletal muscle |
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Authors: | A Reinert A Kaske S Mense |
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Institution: | Institut für Anatomie und Zellbiologie, Universit?t Heidelberg, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany e-mail: mense@novsrvl.piol.uni-heidelberg.de, Fax: +49–6221–54–60–71, DE
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Abstract: | The density of substance P (SP)-, calcitonin gene-related peptide (CGRP)- and vasoactive intestinal polypeptide (VIP)-immunoreactive
(ir) nerve endings was quantitatively evaluated in intact and inflamed gastrocnemius-soleus muscle of the rat. In persistently
inflamed muscle (12 days after a single injection of Freund’s adjuvant into the muscle), the density of SP-ir fibres was significantly
increased. CGRP- and VIP-ir fibres displayed an insignificant increase in density. The density of fibres ir for nerve growth
factor (NGF) and for growth-associated protein 43 (GAP-43/B-50), a marker for axonal sprouting, regeneration and synaptic
reorganisation, increased significantly in persistently inflamed muscle. The data are consistent with the established contribution
of NGF on the expression of SP and GAP-43 in afferent neurones under the influence of a persistent inflammation.
Received: 8 September 1997 / Accepted: 12 February 1998 |
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Keywords: | Substance P Nerve growth factor Growth-associated protein 43 Nerve endings Myositis Rat |
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