Effect of recombinant basic fibroblast growth factor (bFGF) on fibroblast-like cells from human rotator cuff tendon |
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| Authors: | Takahasih Shu Nakajima Mizuho Kobayashi Moto Wakabayashi Ikuko Miyakoshi Naohisa Minagawa Hiroshi Itoi Eiji |
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| Institution: | Department of Orthopedic Surgery, Akita University School of Medicine, Akita 010-8543, Japan. shu@med.akita-u.ac.jp |
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| Abstract: | Rotator cuff tendon cells (RCC) derived from surgical samples showed fibroblast-like morphology. Histological staining demonstrated collagen secretion by RCC. Immunohistological findings revealed that RCC secreted type I and III collagen, but not type II collagen. In addition, the SDS-PAGE analysis suggested that RCC predominantly produced type I collagen. Basic fibroblast growth factor (bFGF) had a stimulatory effect on the proliferation of RCC dose-dependently up to 1 ng/ml. Administration of bFGF suppressed the secretion of collagens from RCC in a dose-dependent manner. |
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