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| 包涵体肌炎11例临床及组织病理报告 | |
| 引用本文： | 闵丹琳,王鲁宁,沈定国,Anne Lacey. 包涵体肌炎11例临床及组织病理报告[J]. 中华神经科杂志, 2001, 34(5): 299-301 |
| 作者姓名： | 闵丹琳 王鲁宁 沈定国 Anne Lacey |
| 作者单位： | 1. Department of Neurology, Pennsylvania University,Philadelphia19104-6087,USA 2. 解放军总医院神经科 3. Department of Neurology, Pennsylvania University,Philadelphia 19104-6087,USA |
| 基金项目： | 卫生部科学研究基金资助项目(96-1-308) |
| 摘 要： | 目的 探讨包涵体肌炎的诊断标准。方法 分析了11例包涵体肌炎病人的临床表现、组织化学。碱性刚果红染色9例,电镜检查2例。结果 全部病人均在42岁后发病,表现为远、近端肌肉力弱,2例肌电图检查显示肌源性改变,11例均有边缘着色性空泡及炎性改变,9例有淀粉样蛋白沉积物,有胞核或胞质细丝包涵体各1例。结论 包涵体肌炎的所有诊断指标中,无一项有决定性或行征性,需要进行综合判断。 |
| 关 键 词： | 包涵体肌炎 病理学 临床表现 发病机制 肌纤维变性 |
| 修稿时间： | 2000-10-08 |
Inclusion body myositis: clinical and histochemical study in 11 cases |
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| Anne Lacey. Inclusion body myositis: clinical and histochemical study in 11 cases[J]. Chinese Journal of Neurology, 2001, 34(5): 299-301 | |
| Authors: | Anne Lacey |
| Abstract: | Objective To further discuss the diagnostic criteria for characterize of inclusion body my ositis (IBM). Methods Clinical features, muscle histochem istry in 11 cases, Congo-Red staining in 9, electronmicroscopic examination i n 2 have been investigated. Results Symptoms usually began after age 42 in all cases. Muscle weakness was involved in both proximal and distal muscles. EMG s ho wed my ogenic changes in 2 cases, while rimmed vacuoles and cellular infiltration were f ound in all muscle samples. Congo-Red-positive amyloid deposits were found in 9 tested muscles; Tubulofilamentous inclusion bodies were found in 2 cases. Conclusion The major histopathological changes in sporadic IBM muscles reviewed are not i ndividually specific but taken together they present a specific pattern for spor adic IBM. |
| Keywords: | Myositis inclusion body Pathology |
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