喹硫平联合碳酸锂治疗躁狂症的临床对照研究

目的：比较喹硫平与氯氮平联合碳酸锂治疗躁狂症的疗效及安全性。方法：将符合CCMD-3诊断标准的60例躁狂症患者，随机分为两组，在使用碳酸锂的基础上分别合并喹硫平或氯氮平进行为期6周的治疗，用BRMS评定疗效，用TESS评定不良反应。结果：喹硫平组与氯氮平组治疗躁狂症状均有显著性改善，有效率分别是93．3％和90％，疗效相当。药物不良反应喹硫平组显著少于氯氮平组。结论：喹硫平合并碳酸锂治疗躁狂症安全有效，依从性好。

A case control study of quetiapine with lithium therapeutic mania

Objective:To compare the therapeutic effects and safety between admininstration of clozapine with lithium carbonate and administration of quetiapine with lithium carbonate for treating mania.Methods:60 patients diagnosed as mania according to CCMD-3 were randomly divided into two groups,one group receiving 6 weeks of administration of quetiapine with lithium carbonate(quetiapine group) and the other receiving 6 weeks of administration of clozapine with lithium carbonate(clozapine group).The therapeutic effects were evaluated by BRMS and side effects were evaluated by TESS.Results: Both quetiapine group and clozapine group showed significant and similar improvement in symptoms of mania,with effective rate of 93.3% for the former and 90% for the latter.But,quetiapine group showed significantly lower scores of side effects by TESS than did clozapine group.Conclusions: administration of quetiapine with lithium carbonate can be effective and safe in treatment of mania,which may possess beneficial compliance with mania patients.