肾病患者血清胱抑素C检测的临床应用

目的探讨血清胱抑素C（CysC）水平在肾病患者中的临床应用价值。方法采用免疫比浊法测定2011年5～6月该院80例住院肾病患者的血清CysC水平,同时采用酶法测定血清肌酐（SCR）水平,并以167例健康体检者为对照组。结果肾病患者组血清CysC水平为（2.91±2.09）mg/L,SCR水平为（287.26±283.65）μmol/L,分别高于对照组CysC水平（0.90±0.24）mg/L及SCR水平（62.63±19.02）μmol/L（P〈0.05）;肾病组CysC阳性率明显高于SCR阳性率,但差异无统计学意义（P〉0.05）。结论血清CysC在肾病患者中有较高的检出率,是反映肾病患者肾损害的良好指标。

Patients with nephropathy serum cystatin C detection clinical application

Objective To investigate the clinical value of serum cystatin C（CysC） leve in patients with kidney disease.Methods From May 2011 to June,80 hospitalized patients with kidney disease were tested about serum CysC level,enzymatic determination of the level of serum creatinine（SCR） by immune turbidimetric method,and 167 healthy subjects were control group.The mean serum CysC level was（2.91±2.09）mg/L and the mean SCR level was（287.26±283.65）μmol/L in kidney disease patients,these were significantly higher than control group with serum CysC level of（0.90±0.24）mg/L and SCR level of（62.63±19.02）μmol/L（P0.05）.In kidney diseas group,positive rate of CysC was significantly higher than SCR,but the difference was not statistically significant（P0.05）Results Conclusion Serum CysC in patients with kidney disease has a higher detection rate,it is a good indicator for reflecting kidney disease in patients with renal impairment.