同期推量调强放射治疗脑转移瘤临床分析

目的：探讨脑转移瘤患者采用同期推量调强放疗的近期疗效和毒副作用。方法：120例患者随机分为研究组即同期推量调强放疗组（SIB）和对照组即全脑放疗联合三维适形放疗组（WBRT＋3D—CRT），每组60例。结果：放疗结束时影像学检查疗效：研究组和对照组完全缓解率（CR）分别为70．0％和46．7％，有显著性差异（P=0．010）。总有效率研究组和对照组分别为90．9％和81．7％，无显著性差异（P=0．191）。1年生存率研究组和对照组分别为68．3％和45．O％，有显著性差异（P=0．007）。急性不良反应发生率研究组和对照组分别为21．7％和18．3％，无显著性差异（P=0．648）。平均住院时间研究组和对照组分别为24天和44天，有显著性差异（P=0．000）。结论：同期推量调强放疗治疗脑转移瘤疗效好，能够改善患者生活质量，延长生存期，毒副作用无增加，而且缩短了治疗疗程。值得临床推广应用。

Clinical analysis of intensity -modulated radiotherapy for brain metastatic tumor with simultaneous integrated boost technique

Objective ：To explore the short - term efficacy and side effects of intensity - modulated radiotherapy for brain metastatic tumor patients with simultaneous integrated boost technique. Methods：All 120 patients were random- ized into research group treated with simultaneous integrated boost intensity- modulated radiotherapy （SIB） and con- trol group treated with three - dimensional conformal radiotherapy combined with whole brain radiotherapy （ WBRT ＋ 3D -CRT） ,each group with 60 patients. Results：After radiotherapy, imaging curative effects were： complete remis- sion （CR） rates in the two groups 70.0% and 46.7% respectively , P -- 0. 010. The total efficacy rates were 90.9% and 81.7% ,P =0. 191.1 - year survival rates were 68.3% and 45.0% ,P = 0. 007. Acute side effects occurrence rates were 21.7 % and 18.3 % , P = 0.648. The mean hospital stay time were 24 days and 44 days, P = 0. 000. Con- clusion ： Simultaneous integrated boost intensity - modulated radiotherapy has good curative effects for brain metastatic tumor and can improve patients＂ life quality, prolong survival time, reduce the treatment course and side effects do not