DEK 的表达与结直肠癌患者预后的相关性研究

目的：采用免疫组化技术，分析DEK基因在结直肠癌患者中的表达情况及其与预后的相关性。方法：运用免疫组化SP法，检测DEK基因在169例结直肠癌患者肿瘤组织及癌旁组织中的表达情况，并运用统计分析软件分析DEK表达水平与结直肠癌患者预后的相关性。结果：DEK的表达率在结直肠癌组织（85／169，50．30％）明显高于癌旁正常组织（28／169，16．57％），差异具有统计学意义（P〈0．01）。DEK在肿瘤组织中的表达情况与病人年龄、性别、肿瘤分化程度、TNM分期及肿瘤大小等因素无相关性，与总生存率（OS）显著相关（P〈0．05）。结论：DEK表达水平与结直肠癌预后密切相关，DEK高表达的结直肠癌患者预后较差。

Expression and prognostic significance of DEK in human colorectal carcinoma

Objective ：To analyze DEK gene expression and prognostic significance in human colorectal carcinoma by using immunohistochemical techniques. Methods ：Immunohistochemical SP method was used to test the expression of DEK gene in 169 eases of colorectal cancer tissue and para - carcinoma tissue, and statistical analysis software was used to analyze the correlation between DEK gene expression and prognostic significance in human colorectal carcino- ma. Results：The expression rate of DEK in colorectal cancer tissue 85/169 （50.30%） was significantly higher than those in para - carcinoma tissue,28/169 （ 16.57% ） （ P 〈 0.01 ）. The level of DEK expression in the tumor tissues was irrelevant to age, gender, differentiated degree, TNM stage and location, but significantly correlated with overall survival（OS） （ P 〈 0.05 ）. Conclusion： DEK expression is closely related to the prognosis of colorectal cancer. There will be poor prognosis for colorectal cancer patients with high DEK expression.