| 盐酸塞利洛尔合成工艺改进 |
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| 引用本文： | 王礼琛,任进知,韦万武,刘春河.盐酸塞利洛尔合成工艺改进[J].中国现代应用药学,1998,15(6):35-36. |
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| 作者姓名： | 王礼琛 任进知 韦万武 刘春河 |
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| 作者单位： | 中国药科大学有机化学教研室南京 210009 |
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| 摘 要： | 目的:合成盐酸塞利洛尔,并进行工艺改进。方法:革除溴化反应,对醚化反应进行了优化。结果:使合成路线缩短一步,醚化收率比文献值提高20％以上。结论:该路线较适合于工业化生产。
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| 关 键 词： | 塞利洛尔 盐酸 合成工艺 对氨基苯乙醚 |
Improved synthesis of celiprolol hydrochloride |
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| Wang Lichen.Improved synthesis of celiprolol hydrochloride[J].The Chinese Journal of Modern Applied Pharmacy,1998,15(6):35-36. |
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| Authors: | Wang Lichen |
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| Abstract: | OBJECTIVE: Synthesis of celiprolol hydrochloride and the improvement of the process. METHODS:Abolishing of brominating step and optimizing of etherifying reaction. RESULTS: Synthetic route was shorten by one step, the yield of etherification increased by 20% or more as compared with the yield in literature.CONCLUSION:The route is more suitable for manufacture. |
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| Keywords: | Celiprolol Hydrocholride 4 - aminophenylethyl ether N N - diethylaminoformyl chloride |
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