Maspin蛋白在葡萄胎恶变中的作用 |
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引用本文: | 白莎莎,庞义存,田腊梅,赵欢.Maspin蛋白在葡萄胎恶变中的作用[J].中国医学文摘:计划生育妇产科学,2011(6):10-13. |
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作者姓名: | 白莎莎 庞义存 田腊梅 赵欢 |
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作者单位: | 河北医科大学第三医院妇产科; |
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基金项目: | 国家自然科学基金项目(30772317); 河北省科技厅科研基金项目(09276101D-30) |
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摘 要: | 目的探讨Maspin(Mammary Serpin)基因在葡萄胎组织中的表达,了解Maspin基因在葡萄胎发生发展及恶变中的作用。方法对50例葡萄胎组织(其中8例发生恶变)及正常早孕绒毛20例(对照组)采用免疫组化链霉菌抗生物素蛋白一过氧化物酶连接(streptavidin-biotin peroxidase,SP)法,测定组织中Maspin的表达。结果Maspin阳性表达率分别为:葡萄胎组60%(其中未恶变葡萄胎组78.6%;恶变葡萄胎组37.5%);对照组90%。葡萄胎组Maspin蛋白阳性表达率低于对照组,差异有统计学意义(P〈0.05);恶变葡萄胎组Maspin蛋白阳性表达率低于未恶变葡萄胎纽,差异有统计学意义(P〈0.05)。结论Maspin的表达下调可能在葡萄胎的发生发展中起着重要的作用,Maspin的表达可能对葡萄胎的发生及恶性转化起抑制作用。
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关 键 词: | 葡萄胎 恶变 Maspin 侵袭性 免疫组织化学 |
The effect of Maspin on malignant transformation of hydatidiform mole |
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Authors: | BAI Sha-sha PANG Yi-cun TIAN La-mei ZHAO Huan |
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Institution: | BAI Sha-sha,PANG Yi-cun,TIAN La-mei,ZHAO Huan Department of Obstetrics and Gynecology,The Third Hospital of Hebei Medical University,Shijiazhuang Hebei 050001,P.R.China |
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Abstract: | Objective To investigate the expression of Maspin in hydatidiform mole and the effect of Maspin(Mammary Serpin)on malignant transformation of hydatidiform mole.Methods Immunohistochemistry was used to analyze Maspin expression in 50 cases with hydatidiform mole including 8 cases with malignant transformation of hydatidiform mole and 20 cases with normal chorion(as control group).Results The positive rate of Maspin staining was 60% in hydatidiform mole issues(including 78.6% in hydatidiform mole issues witho... |
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Keywords: | hydatidiform mole Maspin malignant transformation immunohistochemistry |
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