骨组织工程支架材料聚磷酸钙生物陶瓷研究进展

为修复创伤及病理因素导致的骨缺损,骨组织工程是一项迅速发展、不断革新的课题。多孔聚磷酸钙生物陶瓷是可吸收生物陶瓷的一种,具有良好的生物相容性以及可降解性,在骨组织工程中日益被人们所认识。骨组织工程中细胞生长速率与材料的降解速率相匹配一直是有待解决的问题,聚磷酸钙由于具有独特的结构及降解性能,因此有望解决这个问题。本文对作为骨组织工程支架材料之一的聚磷酸钙生物陶瓷的理化性质、制备方法、研究进展、骨结合机理等进行了综述,并对其研究和发展作出了展望。

Advances in Research on Calcium Polyphosphate Bioceramic for Bone Tissue Engineering Scaffold

Bone tissue engineering is a novel, developing and challenging science which provides a new way to repair bone lost from injury and disease. Porous calcium polyphosphate bioceramic is one kind of absorptable bioceramic. Owing to its fine biocompatibility and degradability, more and more pieces of research wark have been carried out in bone tissue engineering,and because of its special characteristics, calcium polyphosphate bioceramic is regarded as a promising material for solving the problem of how to match the degradation velocity of scaffold with the velocity of cell growth. The recent research of using calcium polyphosphate bioceramic as the scaffold in bone tissue engineering is summarized, including the property, synthesis and advances.