轻刺激——从克罗米芬到来曲唑

长方案、短方案已在临床使用了20余年,这类超排卵方案采用降调节抑制内源性卵泡刺激素(FSH)、黄体生成素(LH)合成和释放,降低了过早排卵导致的周期取消,但也导致了促性腺激素用量大增、促排卵时间延长,即使是卵巢储备正常者也可能出现超排卵反应低下导致周期取消;卵巢储备低下患者则因不能超排而无缘体外受精胚胎移植(IVF-ET);同时,垂体抑制使卵巢反应增加,重度卵巢过度刺激综合征(OHSS)发生率增加.因传统的超排卵技术有上述不足,最近几年关于微刺激或轻刺激的讨论逐渐增多,轻微卵巢刺激的理念已被业界所认可1-3].

Mild stimulation-from clomiphene to letrozole

From October 2006,we began to investigate two kinds of mild stimulation protocols which were CC+HMG and L+HMG.Our preliminary results show:(1)119 patients were stimulated with CC+HMG,143 oocyte pick-up(OPU) cycles have been finished.The average age of patient was 33.9 years old.5.64 eggs were retrieved per patient averagely.Fertilization rate was 63.4%.The 143 OPU cycles resulted in 59 fresh embryo transfer cycles(11 clinical pregnancies),55 whole embryo frozen cycles and 29 cycles without available embryo(...