| RNA干涉技术在基础医学中的研究进展 |
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| 引用本文： | 杨安安.RNA干涉技术在基础医学中的研究进展[J].亚太传统医药,2008,4(2):32-34. |
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| 作者姓名： | 杨安安 |
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| 作者单位： | 中国人民解放军第四军医大学药学系,陕西,西安,710032 |
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| 摘 要： | RNA干涉(RNA interference,RNAi)是由双链RNA(double strand RNA,ds RNA)引起的转录后基因沉默机制,具有序列特异性和高效性,RNAi作为一门新的基因阻断技术,在基础医学研究及基因治疗中具有广阔的应用前景。对RNAi作用机制及其在疾病发病机制及治疗方面的研究进展进行了概述。
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| 关 键 词： | RNA干涉 基因阻断技术 基因沉默 |
| 文章编号： | 1673-2197（2008）02-032-03 |
| 收稿时间： | 2007-12-16 |
Study Progress of RNA Interference in Preclinical Medicinel Research |
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| Yang An'an.Study Progress of RNA Interference in Preclinical Medicinel Research[J].Asia-Pacific Traditional Medicine,2008,4(2):32-34. |
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| Authors: | Yang An'an |
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| Institution: | Yang An＇an(The First Team of Pharmacy Department, The Fourth Military Medical University, Xi＇an 710032,China) |
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| Abstract: | RNA interference （RNAi） is a phenomenon by which the double stranded RNA （dsRNA） induces targeted degradation of RNA molecules with homologous sequences in vitro and in vivo. It has some features such as specific,efficient and quick etc. RNAi is a new tool for silencing gene expression. RNAi is currently used for both clinic medical study and gene specific therapeutic intervention that target the mRNAs of pathogenic genes. Here the mechanism and application of RNAi are reviewed. |
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| Keywords: | RNA interference Gene silence Etiological treatment |
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