| 脑络通胶囊抗鹌鹑动脉粥样硬化的实验研究 |
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| 引用本文： | 马杰,周群,杜佳林,郭力辉,张秀敏,洪治平.脑络通胶囊抗鹌鹑动脉粥样硬化的实验研究[J].中国动脉硬化杂志,1998,6(2):159-161. |
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| 作者姓名： | 马杰 周群 杜佳林 郭力辉 张秀敏 洪治平 |
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| 作者单位： | 辽宁省中医研究院病理生理室!沈阳110031 |
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| 基金项目： | 国家“八·五”科技攻关课题 |
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| 摘 要： | 为探讨脑络通胶囊抗鹌鹑动脉粥样硬化的机制，以食饵性高脂血症鹌鹑复制动脉粥样硬化模型，测量其血清中总胆固醇、甘油三脂，血浆中前列环素、血栓烷A2，脑组织中过氧化脂质、超氧化物歧化酶和谷胱甘肽过氧化物酶，并用评分法评估鹌鹑动粥样硬化的程度。结果发现，脑络通胶囊无降胆醇和甘油三酯的作用，但能显著升高超氧化物歧化酶的含量（P＜0．05），减轻动脉粥样硬化斑块的形成（P＜0．05）。提示，脑络通胶囊抑制动脉粥样硬化斑块形成的机理不是通过降血脂作用，而是通过抗氧化作用而奏效的。
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| 关 键 词： | 脑络通胶囊 动脉粥样硬化 鹌鹑 |
| 收稿时间： | 1997/7/8 0:00:00 |
| 修稿时间： | 1998/4/10 0:00:00 |
Effects of Naoluotong Capsule on Experimental Atherosclerosis in Quails |
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| MA Jie; ZHOU Qun; DU Jia-Lin; GUO Li-Hui;ZHANG Xiu-Min and HONG Zhi-Ping.Effects of Naoluotong Capsule on Experimental Atherosclerosis in Quails[J].Chinese Journal of Arteriosclerosis,1998,6(2):159-161. |
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| Authors: | MA Jie; ZHOU Qun; DU Jia-Lin; GUO Li-Hui;ZHANG Xiu-Min and HONG Zhi-Ping |
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| Institution: | Liaoning Academy of Traditional Chinese Medicine, Shengyang 110031, China |
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| Abstract: | Aim: To study the mechanism of naoluotong on anti-atherosclerosis in quails.Methods: After the atherosclerosis (As) model in hyperlipemia quails were made,we measured the total cholesterol (TC ) and triglyceride (TG ) in serum, prostacyclin (PGI2 ) and thromboxane A2 (TXA2 ) in plasma, lipid peroxidation (LPO) and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)in brain tissuse. we estimated the grade of As by given points.Results: Naoluotong have no effects of reducing the amount of TC and TG, but increasing the amount of SOD (P<0. 05) and alleviating the formation of As plaque (P<0.05).Conclusion: The mechanism of naoluotong on inhibiting the formation of As plaque is not reducing hyperlipermia but antioxidation. |
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| Keywords: | Naoluotong capsule Atherosclerosis Quail |
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