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| The V264M polymorphism of tissue factor pathway inhibitor gene in patients with acute coronary syndrome | |
| 引用本文： | Tiebing Zhu,Jun Wang,Leming Fan,Yong Li,Zhijian Yang,Kejiang CAO,Jun Huang. The V264M polymorphism of tissue factor pathway inhibitor gene in patients with acute coronary syndrome[J]. 南京医科大学学报(自然科学版), 2006, 20(5): 271-274 |
| 作者姓名： | Tiebing Zhu Jun Wang Leming Fan Yong Li Zhijian Yang Kejiang CAO Jun Huang |
| 作者单位： | [1]Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029 [2]Atherosclerotic Reaserch Center of Nanjing Medical University, Nanjing 210029, China |
| 基金项目： | Education Department of Jiangsu Province（01KJB32006） |
| 摘 要： | Objective： To investigate V264M polymorphism of tissue factor pathway inhibitor （TFPI） in patients with acute coronary syndrome （ACS） in Chinese. Methods ： The genotypes of V264M were detected by polymerase chain reaction （PCR） and restriction fragment length polymorphism （PCR-RFLP） in 136 patients with ACS and 106 healthy controls with their plasmal f-TFPI tested by enzyme linked immunosorbent assay （ELISA）. Results： Two genotypes were found in V264M： GG and GA. The distribution frequencies of alleles and genotypes were in accordance with those predicted by Hardy Weinberg equilibrium in the present study （χ2 = 0.437, P 〉 0.05）. Plasma f-TFPI level was lower in A allele bearer than that in non-A allele carriers and higher in ACS than control subjects （P〈0.05）. No relationship was found between ACS and V264M polymorphism （P〉0.05）. Conclusion： The V264M polymorphism may have an impact on the plasma level of free TFPI（f-TFPI）, but it has no relationship with ACS. |
| 关 键 词： | V264M 基因多态性 急性冠状综合症 病理机制 |
| 收稿时间： | 2006-03-22 |
The V264M polymorphism of tissue factor pathway inhibitor gene in patients with acute coronary syndrome |
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| Tiebing Zhu,Jun Wang,Leming Fan,Yong Li,Zhijian Yang,Kejiang CAO,Jun Huang. The V264M polymorphism of tissue factor pathway inhibitor gene in patients with acute coronary syndrome[J]. Acta Universitatis Medicinalis Nanjing, 2006, 20(5): 271-274 | |
| Authors: | Tiebing Zhu Jun Wang Leming Fan Yong Li Zhijian Yang Kejiang CAO Jun Huang |
| Abstract: | Objective: To investigate V264M polymorphism of tissue factor pathway inhibitor (TFPI) in patients with acute coronary syndrome(ACS) in Chinese. Methods: The genotypes of V264M were detected by polymerase chain reaction(PCR) and restriction fragment length polymorphism(PCR-RFLP) in 136 patients with ACS and 106 healthy controls with their plasmal f-TFPI tested by enzyme linked immunosorbent assay(ELISA). Results: Two genotypes were found in V264M: GG and GA. The distribution frequencies of alleles and genotypes were in accordance with those predicted by Hardy Weinberg equilibrium in the present study(?2 = 0.437, P > 0.05). Plasma f-TFPI level was lower in A allele bearer than that in non-A allele carriers and higher in ACS than control subjects (P < 0.05). No relationship was found between ACS and V264M polymorphism(P > 0.05). Conclusion: The V264M polymorphism may have an impact on the plasma level of free TFPI(f-TFPI), but it has no relationship with ACS. |
| Keywords: | acute coronary syndrome TFPI polymorphism plasma |
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