| 损伤面神经核游离钙离子水平与r-氨基丁酸A受体的负向调控 |
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| 引用本文： | 朱富高,孙大为,王岩青,周锐,温君凤,万秀明,王彦君,刘邦华. 损伤面神经核游离钙离子水平与r-氨基丁酸A受体的负向调控[J]. 中国神经再生研究, 2010, 5(22): 1756-1760 |
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| 作者姓名： | 朱富高 孙大为 王岩青 周锐 温君凤 万秀明 王彦君 刘邦华 |
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| 作者单位： | Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China,青岛大学医学院附属医院耳鼻咽喉头颈外科,青岛大学医学院附属医院科教部,College of Public Health, Shandong University, Jinan 250012, Shandong Province, China,Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China,Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China,Department of Otolaryngology-Head and Neck Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China,Department of Otolaryngology-Head and Neck Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China |
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| 基金项目： | 青岛大学青年科研基金项目（2007） |
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| 摘 要： | ![]()
目前面神经损伤修复的机制尚未阐明，揭示面神经损伤后神经修复再生的病理生理机制，最大程度地恢复面神经功能，是学者们面临的一个重要问题。在前期研究中，本课题组发现毒蕈碱受体和烟碱受体通过不同的机制调控面神经核细胞内游离钙离子的水平。并且面神经损伤后，毒蕈碱受体和烟碱受体通过不同机制使面神经核游离钙离子浓度达到更高水平，为面神经的再生修复的一系列反应提供了重要条件。但是，细胞内钙离子水平增高到一定程度可以使细胞发生钙超载而死亡。γ-氨基丁酸（GABA）是中枢神经系统重要的抑制性神经递质，GABAA受体在面神经再生修复中对胆碱能受体效应的调控及机制目前仍为一空白领域。为了探讨GABAA受体在面神经损伤修复中的作用，本研究中建立面神经损伤动物模型，通过免疫组织化学、原位杂交和激光共聚焦显微镜技术首次系统研究了大鼠面神经核中GABAA受体的表达以及面神经损伤后GABAA受体对烟碱受体效应的调控。研究发现在面神经核至少存在GABAA的α1、α3、α5、β1、β2、δ、γ3亚单位。并且面神经损伤后GABAA受体对烟碱受体介导的面神经核游离钙离子水平增高的效应有显著的抑制效应(P<0.05)，呈浓度依赖性。因此，通过本课题组一系列研究，我们认为周围性面神经损伤后，面神经核游离钙离子浓度至少受到毒蕈碱受体、烟碱受体的正向调控和GABAA受体的负向调控，从而为面神经再生修复提供合适的钙离子水平。
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| 关 键 词： | 面神经损伤；γ-氨基丁酸A受体；面神经核；钙离子；周围神经损伤；神经再生 |
Negative regulation of gamma-aminobutyric acid type A receptor on free calcium ion levels following facial nerve injury |
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| Zhu Fugao,Sun Dawei,Wang Yanqing,Zhou Rui,Wen Junfeng,Wan Xiuming,Wang Yanjun and Liu Banghua. Negative regulation of gamma-aminobutyric acid type A receptor on free calcium ion levels following facial nerve injury[J]. Neural Regeneration Research, 2010, 5(22): 1756-1760 |
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| Authors: | Zhu Fugao Sun Dawei Wang Yanqing Zhou Rui Wen Junfeng Wan Xiuming Wang Yanjun Liu Banghua |
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| Affiliation: | Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China,Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China,Department of Science and Education, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China,College of Public Health, Shandong University, Jinan 250012, Shandong Province, China,Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China,Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China,Department of Otolaryngology-Head and Neck Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China,Department of Otolaryngology-Head and Neck Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China |
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| Abstract: | ![]()
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| Keywords: | facial nerve injury GABAA receptor facial nucleus calcium ion peripheral nerve injury neural regeneration |
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