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HLA—DR specificities among Japanese with several autoimmune diseases |
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| Authors: | Takehiko Sakurami Yukio Ueno Yuichi Iwaki Min S. Park Paul I. Tsrasako Hiroo Saji Shirley Louie Steve Takemura |
| Affiliation: | First Division of Internal Medicine. Shimane Medical University, Izumo, Japan;Second Division of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan;Department of Surgery, School of Medicine, University of California, Los Angeles, CA, U.S.A.;The Kyoto Red Cross Blood Center, Kyoto, Japan. |
| Abstract: | HLA—A,—B,—C, and—DR antigens were determined in order to study the association of HLA in Japanese patients with several autoimmune diseases, hypertrophic cardiomyopathy, and Hodgkin's disease. The frequency of HLA—DR4 was significantly increased in the patients with rheumatoid arthritis, juvenile-onset insulin-dependent diabetes mellitus (IDDM) and hypertrophic obstructive cardiomyopathy. In this study, no significant associations with A, B, or C specificities were observed except BW22 in IDDM. In contrast, the negative association with HLA—DR2 was observed in Hashimoto's thyroiditis, pemphigus vulgaris and hypertrophic non-obstructuve cardiomyopathy. |
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