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Plasma cytokines in graft vs host disease and complications following bone marrow transplantation |
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| Authors: | A. N. Abdallah J. M. Boiron Y. Attia A. Cassaigne J. Reiffers A. Iron |
| Affiliation: | (1) Département de Biochimie Médicale et Biologie Moléculaire, Université de Bordeaux 2, 146, Rue Léo-Saignat, F-33076 Bordeaux Cedex, France;(2) Unité de Greffe de Moelle, CHU de Bordeaux, Avenue Magellan, F-33604 Pessac, France;(3) Laboratoire de Biochimie, Hôpital Pellegrin, CHU de Bordeaux, Place Amélie-Raba-Léon, F-33076 Bordeaux Cedex, France |
| Abstract: | A cohort of 201 autologous or allogeneic bone marrow transplanted (BMT) patients were included for studying the evolution of circulating tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) by means of repeated plasma determinations. IL-6 levels were high during major transplant-related complications (TRC) or severe graft vs host disease (GVHD). High levels of TNF-alpha seemed to be associated with chronic GVHD but not with acute GVHD or TRC. |
| Keywords: | Bone marrow transplantation Interleukin 6 Tumor necrosis factor-alpha Graft vs host disease |
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