| Sonic Hedgehog与前列腺生长调控 |
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| 引用本文： | 杨立,申吉泓,刘孝东. Sonic Hedgehog与前列腺生长调控[J]. 中华男科学杂志, 2007, 13(8): 730-733 |
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| 作者姓名： | 杨立 申吉泓 刘孝东 |
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| 作者单位： | 昆明医学院第一附属医院泌尿外科,云南,昆明,650032 |
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| 摘 要： | Sonic hedgehog(Shh)是一类在胚胎发育过程中起关键作用的信号调节因子。研究认为Shh信号在前列腺导管形成分化以及基质-上皮的相互作用等机制中发挥着重要作用,从而调节前列腺发育、生长和细胞增殖;Shh信号作用途径的紊乱可导致肿瘤细胞的生成和增殖。探讨Shh信号机制在前列腺正常生长和疾病状态中的作用将为研究前列腺疾病的发病机制提供重要的思路。
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| 关 键 词： | Sonic hedgehog 信号蛋白 前列腺 生长调控 |
| 文章编号： | 1009-3591（2007）08-0730-04 |
| 收稿时间： | 2006-07-14 |
| 修稿时间： | 2006-07-142006-10-23 |
Sonic Hedgehog and Prostate Growth Regulation |
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| YANG Li,SHEN Ji-hong,LIU Xiao-dong. Sonic Hedgehog and Prostate Growth Regulation[J]. National journal of andrology, 2007, 13(8): 730-733 |
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| Authors: | YANG Li SHEN Ji-hong LIU Xiao-dong |
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| Affiliation: | Department of Urology, First Affiliated Hospital of Kunming Medical College, Kunming , Yunnan 650032, China |
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| Abstract: | Sonic hedgehog(Shh)is a key signal regulatory factor in embryonic development.It is reported that Shh signaling plays important roles in prostatic duct differentiation and matrix-epithelium interaction,and thus regulates the development,growth and cell proliferation of the prostate.A disorder in Shh signaling will lead to the production and proliferation of tumor cells.An exploration into the mechanism of Shh signaling in the normal growth and diseased condition of the prostate will offer some significant ideas for the studies on the pathogenesy of prostate diseases. |
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| Keywords: | Sonic hedgehog |
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