手足口病密切接触儿童预防用药后病原体阳性检出率分析

目的：分析手足口病（HFMD）密切接触儿童预防用药后病原体阳性检出率的变化，为HFMD的预防提供科学依据。方法：将HFMD密切接触儿童1106例分为预防1组（用中药）、预防2组（用中药加干扰素）、预防3组（用干扰素）、对照组（空白对照），统计各组HFMD发病率，并从中随机抽取282例儿童采集大便标本，进行EV71和CoxA16病毒PCR检测。结果：（1）发病率各预防组与对照组比较差异有统计学意义（P〈0．001），各预防组之间差异无统计学意义（P〉0．05）。（2）各组间、各组内发病与未发病儿童大便标本Ev71和CoxA16病毒PCR总阳性率比较差异均无统计学意义（P〉0．05）。结论：预防用药能显著降低HFMD发病率，但不能降低EV71和CoxA16病毒PCR总阳性检出率，其原因可能与投药剂量或其他因素有关。

Analyses of the pathogen positive detection rate in close contact with hand,foot and mouth disease children after preventive medication

Objective： To analyze the variations of pathogen positive detection rate in close contact with hand, foot and mouth disease （HFMD） children after preventive medication, and to provide scientific basis for HFMD prevention. Methods： 1 106 cases of close contact with HFMD Children were divided into four groups, prevention groupl （TCM group）, prevention group 2（ TCM ＋ IFN group）, prevention group 3 （IFN group） and control group （blank control group）. The incidence of HFMD was calculated, and stool samples of 282 cases of children were tested for enterovirus 71 （ EV71 ） and coxsackievirus A16 （ CoxA16 ） using polymerase chain reaction （PCR） method. Results： There was a significant difference between the incidences of HFMD in every preventive group and control group （P 〈 0. 001 ）. But there was no statistical difference among the three preventive groups（P 〉 0. 05 ）. The EV71 and CoxA16 virus PCR total positive detection rates in the four groups,or between children with HFMD and those without HFMD inside each groups were not significantly different （ P 〉 0. 05 ）. Conclusion： Preventive medication can significantly reduce the incidence of HFMD, but not reduce the EV71 and CoxA16 virus PCR total positive detection rates. The reason may be associated with drug delivery dosage or other factors.