B‐Cell lymphoproliferative disorder not associated with Epstein‐Barr Virus in a child with relapsed acute lymphoblastic leukemia |
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Authors: | Thomas Lehrnbecher,Andreas Trusen,Frank Deinlein,Burkhard H cht,Alexander Marx,Joachim Kü hl |
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Affiliation: | Thomas Lehrnbecher,Andreas Trusen,Frank Deinlein,Burkhard Höcht,Alexander Marx,Joachim Kühl |
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Abstract: | Lymphoproliferative disorder (LPD) is described in only a few children receiving chemotherapy for cancer. In all of them, an association between LPD and EBV (Epstein‐Barr Virus) was found. We report on a patient who developed LPD not associated with EBV while receiving chemotherapy for relapsed acute lymphoblastic leukemia (ALL). Despite discontinuation of chemotherapy, administration of intravenous immunoglobulins and surgery the patient died. Growing experience with this disorder may allow better treatment options in the future and will show whether LPD not associated with EBV requires different therapeutic strategies. Med Pediatr Oncol 2003;40:13–17, © 2003 Wiley‐Liss, Inc. |
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Keywords: | lymphoproliferative disorder Epstein‐Barr Virus relapsed acute lymphoblastic leukemia |
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