| 肥大细胞白血病临床和实验室检查回顾分析 |
| |
| 引用本文： | 孙烨,郭平,熊树民,吴蓉,康向东.肥大细胞白血病临床和实验室检查回顾分析[J].检验医学,2019(2):180-184. |
| |
| 作者姓名： | 孙烨 郭平 熊树民 吴蓉 康向东 |
| |
| 作者单位： | 上海中医药大学附属普陀医院检验科;上海交通大学医学院附属瑞金医院检验科;上海交通大学医学院附属瑞金医院血液科 |
| |
| 摘 要： | 目的回顾分析1例肥大细胞白血病(MCL)患者的临床及实验室检查特点,以提高临床及实验室技术人员对该病的认知。方法对MCL患者行血细胞分析、细胞形态学分析、流式细胞术免疫表型分析、染色体核型分析及白血病突变基因检查,结合相关文献分析该病临床及实验室检查特点。结果患者以反复腹泻、乏力、皮疹、消瘦、脾大为主要临床表现,外周血及骨髓中肥大细胞(MC)分别占42%和79%。流式细胞术免疫表型为CD45+、CD117++、CD33++、CD13+、CD11b-、CD2++、CD9++、CD123-、CD25部分+、CD34-、CD38-、HLADR-、CD64-、CD15-。细胞遗传学检查未见明显异常。分子生物学检查发现KIT基因F522C突变,最终确诊为MCL。结论 MCL是一种罕见的血液系统恶性肿瘤,具有独特的临床和实验室表现,细胞形态上需注意与相似细胞的鉴别,同时应重点完善分子生物学检查以指导治疗。
|
| 关 键 词： | 肥大细胞白血病 细胞形态学 KIT基因突变 |
Retrospective analysis of clinical and laboratory examinations' characteristics of mast cell leukemia |
| |
| SUNYe,GUO Ping,XIONG Shumin,WU Rong,KANG Xiangdong.Retrospective analysis of clinical and laboratory examinations' characteristics of mast cell leukemia[J].Laboratory Medicine,2019(2):180-184. |
| |
| Authors: | SUNYe GUO Ping XIONG Shumin WU Rong KANG Xiangdong |
| |
| Institution: | (Department of Clinical Laboratory,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;Department of Clinical Laboratory,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;Department of Hematology,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China) |
| |
| Abstract: | SUNYe;GUO Ping;XIONG Shumin;WU Rong;KANG Xiangdong(Department of Clinical Laboratory,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;Department of Clinical Laboratory,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;Department of Hematology,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China) |
| |
| Keywords: | Mast cell leukemia Morphology KIT gene mutation |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
