Her-2／neu和CD138在乳腺癌中表达及意义

目的检测乳腺癌组织中Her-2／neu和CD138的表达情况，探讨二者在乳腺癌中表达的意义和相互关系。方法应用免疫组化方法（S-P法）观察102例乳腺癌，30例乳腺良性病变组织（15例乳腺良性肿瘤与15例正常乳腺组织）Her-2／neu和CD138的表达。结果①102例乳腺癌组织和30例乳腺良性病变组织中Her-2／neu阳性表达率分别为58％和0％，CD138阳性表达率分别为41％-42％和100％。乳腺癌组织中Her-2／neu阳性表达率显著高于其在良性病变组织的阳性表达率（P〈0．01），良性病变组织中CD138阳性表达率显著高于乳腺癌组织（P〈0．015）。②Her-2／neu的表达与乳腺癌的淋巴结转移、临床分期密切相关（P〈o．05）。③CD138表达与乳腺癌的淋巴结转移、临床分期呈负相关（P〈0．05）。结论乳腺癌组织中Her-2／neu阳性表达与CD138的阴性表达显著相关（P〈O．01）。

Expressions of Her-2/neu and CD138 in breast cancer and their significances

Objective Purpose To explore the significance of Her-2/neu and CD138 expression in breast cancer and their correlationship. Methods The expression of Her-2/neu and CD138 were evaluated by immunohistochemistry （S-P method） in 102 cases of breast cancer, 15 cases of benign breast tumor and 15 cases of normal breast tissue. Results O H er-2/neu was expressed in 58 % of the breast cancer tissue and 0% of the breast benign hyperplasia（P〈0. 01）, and CD138 was expressed in 41V00 of the breast cancer tissue and 100% of the breast benign hyperplasia（P〈0.01）. QThe expression of Her-2/neu was closely correlated with lymph node metastasis and clinical stage （P〈0.05）. （〈）The ex- pression of CD138 was closely correlated with lymph node metastasis and clinical stage （P〈0.05）. Conclusion There was significant correlation between the expression increasing of Her-2/neu and decreasing of CD138 in breast cancer （P 〈0.05）.