| 青霉烷砜和氨苄青霉素在小鼠和狗的药代动力学(英文) |
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| 引用本文： | 刘昌孝,王嘉融,吕一丽. 青霉烷砜和氨苄青霉素在小鼠和狗的药代动力学(英文)[J]. 药学学报, 1990, 25(6): 406-411 |
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| 作者姓名： | 刘昌孝 王嘉融 吕一丽 |
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| 作者单位： | 国家医药管理局天津药物研究院，国家医药管理局天津药物研究院，国家医药管理局天津药物研究院 天津 300193，天津 300193，天津 300193 中国药品生物制品检定所，北京 100050 |
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| 摘 要： | 青霉烷砜是一新的β-内酰胺酶抑制剂。本文报告青霉烷砜与氨苄青霉素在小鼠和狗的药代动学,两药血清药物浓度采用TLC法测定。在小鼠分别静脉注射青霉烷砜和氨苄青霉素,前者的药代动力学特征与后者相似,半衰期约为50min,两药均可在中央室和外周室间迅速平衡,并能广泛分布于细胞外液和组织。两药合并静脉注射给药,在两种动物上两药的药代动力学基本互不影响。
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| 关 键 词： | 青霉烷砜 氨苄青霉素 药代动力学 |
| 收稿时间： | 1989-04-14 |
PHARMACOKINETICS OF SULBACTAM AND AMPICILLIN IN MICE AND IN DOGS |
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| CX Liu,JR Wang and YL Lu. PHARMACOKINETICS OF SULBACTAM AND AMPICILLIN IN MICE AND IN DOGS[J]. Acta pharmaceutica Sinica, 1990, 25(6): 406-411 |
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| Authors: | CX Liu JR Wang YL Lu |
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| Affiliation: | Tianjing Institute of Pharmaceutical Research, State Pharmaceutical Administration of China. |
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| Abstract: | Sulbactam is a new beta-lactamase inhibitor. The pharmacokinetic characteristics of sulbactam was similar to ampicillin aider a single intravenous injection of 200 mg/kg in mice with a half-life of approximately 50min. The two drugs appear to equilibrate rapidly between central and peripheral compartments. The Vc and Vd suggest that they are widely distributed in the extracellular fluid and into tissues. Co-administration of sulbactam and ampicillin in mice and in dogs showed essentially no change on the kinetics of either ampicillin or sulbactam. |
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| Keywords: | Sulbactam Ampicillin Pharmacokinetics |
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