抽动秽语综合征患者血清自身抗体与可溶性白介素-6受体表达

目的探讨抽动秽语综合征（TS）患者疾病过程中免疫损伤的相关机制。方法应用抗脑抗体（ABAb）、抗核抗体（ANA）、可溶性白介素-6受体（sIL-6R）及可溶性gp130（sgp130）的ELISA方法商品试剂盒,检测患者和正常人血清中sIL-6R、sgpl30及相应抗体的含量。结果TS组血清sIL-6R、sgp130含量显著高于正常对照组（44．078±15．777）：（30．290±9．048）,P〈0．01;（69．032±24．604）：（47．309±14．137）,P〈0．01）;TS患儿血清ABAb、ANA检出率显著高于对照组（66．7％：3．6％,P〈0．01;53．3％：25％,P〈0．05）。且ABAb水平与sgpl30负相关（r=-0．451,P=0．046）。结论在TS患者血清中sIL-6R、sgp130水平显著增高表明依赖IL-6信号传导的生理功能上调和反馈抑制的网络机制启动;自身免疫相关的损伤机制参与了疾病发生发展的病理生理过程。

Serum levels of autoantibodies and soluble interleukin-6 receptor in patients with Tourette's syndrome

Objective To explore mechanisms underlying the immunologic injury in Tourette＇s syndrome （TS） patients. Methods The serum contents of anti--brain antibody （ABAb）, antinuclear antibody （ANA）, soluble IL-6 receptor （sIL-6R）, and soluble gpl30 （sgpl30） in patients were determined with commercialized ELISA kits. Results The levels of sIL-6R and sgpl30 were significantly elevated in TS compared to control group （44. 078±15. 777 vs 0. 290±9. 048, P〈0.01; 69. 032±24. 604 vs 47. 309 ±14, 137, P 〈 0.01, respectively）. The detection rate of anti--brain antibody, antinuclear antibody in TS was remarkably higher than that in control group （66.7% vs 3.6%, P 〈 0.01 ; 53.3% vs 25%, P 〈 0.05）. The ABAb levels correlated with sgp130 concentration （r =- 0. 451 ,P = 0. 046）. Conclusions The elevated serum levels of sIL--6R and sgpl30 in patients with Tourette＇s syndrome indicated the activation of IL- 6-- dependent signal transduction and initiation of the network mechanism of feedback inhibition, suggesting that the autoimmune-related immunologic injuries may be involved in the pathophysiological process of this disease. [Key words]