地奥司明治疗深Ⅱ度烧伤后早期水肿的疗效分析

目的观察地奥司明对深Ⅱ度烧伤患者早期水肿的临床疗效。方法选择深Ⅱ度烧伤后的早期水肿患者60例,创面主要位于四肢,面积10-30%,随机分为两组,对照组给予常规治疗,治疗组在常规治疗基础上给予地奥司明口服治疗。评估患者治疗前后的肢体肿胀及疼痛程度,并观察药物不良反应、患者创面的愈合时间及创面瘢痕增生情况。结果两组患者治疗前创伤肢体周径、疼痛评分比较无统计学差异（P〉0.05）,治疗后创伤肢体肿胀、疼痛程度较治疗前均有所降低,且与对照组相比,治疗组肢体周径、疼痛评分下降更为显著,差异均有统计学意义（P〈0.05）。两组患者的创面愈合时间比较,治疗组较对照组显著缩短,差异有统计学意义（P〈0.05）。治疗组瘢痕指数较对照组明显降低,愈合情况好转（P〈0.05）。结论地奥司明能够减轻烧伤创面水肿的发生及水肿对组织的破坏,维护内环境稳定,加速创面的修复再生,减少瘢痕形成。

The effects of diosmin for the treatment of edema in deep partial-thickness burn patients

Objective To explore the effects of diosmin for the treatment of edema in deep partial-thickness burn patients. Methods Sixty deep partial-thickness burn patients with edema were enrolled from the hospital, who were divided into control group and therapy group. The patients of control group were treated with regular measurement, while the patients of therapy group were treated with regular measurement and diosmin. The degree of limb swelling and pain were tested before the treatment, and the degree of limb swelling and pain, wound healing time. Results Before the treatment, there was no significant difference in the degree of limb swelling and pain between the two groups（P〉0.05）. After the treatment, the degree of limb swelling and pain in therapy group decreased significantly compared with the control group（P〈0.05）. The wound healing time of therapy gourp was shorter than that of control group（P〈0.05）, and compare with the control group the scar index of therapy group decreased significantly（P〈0.05）. Conclusion Diosmin can reduce the occurrence of edema and tissue damage of burn, maintain stable internal environment and accelerate wound healing.