大剂量阿托伐他汀治疗不稳定型心绞痛的疗效评价

目的探讨不同剂量阿托伐他汀对不稳定型心绞痛的有效性和安全性.方法将78例不稳定性心绞痛患者随机分为两组各39例,治疗组常规治疗加上阿托伐他汀40mg/d,对照组加用阿托伐他汀20mg/d.两组均在治疗前及治疗6个月后测定血脂四项、C反应蛋白水平,观察不良心血管事件及不良反应的发生情况.结果治疗6个月后,两组血脂和C反应蛋白水平有不同程度的降低,与对照组比较,治疗组降低更显著(P<0.05);治疗组患者心血管不良事件发生率更低(P<0.05);两组不良反应事件发生率无显著差异(P>0.05).结论阿托伐他汀强化治疗能改善不稳定型心绞痛患者的预后,在权衡患者药物使用利弊后,推荐40mg/d强化治疗.

The clinical investgatton of different doses of atorvastatin in unstable angina pectoris

Objective To abserve the influenct of different doaes of atorvastatin an the prognosis of unstable angina. Methods 78 cases of patients treated with unstable angina were randomly divided into two groups. In the control groups, 39 patients accepted conventional treatments and Atorvastatin 20mg/d, while in the treatment groups 39 patients accepted conventional treatment and Atorvastatin 40mg/d. Both groups were measured before and after 180d treatment at the four lipids, CRP, and were observed of Re-angina, myocardial infarction and cardiac death and other undesirable occurrence of cardiovascular events. Results The lipid levels of two youps have varying degrees of reduction after treatment. Compared with the control group, the observation group is more obvious（P〈0.05）. The two groups both reduce CRP level after treatment. Compared with the control group, the effect of the abservation group is more obvious（P〈0.05）. With the occurrence of adverse events, the observation group decreased signiificantly compared with the control group（P〈0.05）. Conclusion Atorvastatin intensive treatment can improve the prognosis of patients with unstable angina and intensive treatment after weigh in patients with drug use pros and cons, recommended 40mg/d.