常咯啉在实验性心律失常狗的药代动力学-药效动力学分析

用Harris冠脉结扎法诱发的心律失常狗研究常咯啉药代动力学-药效动力学。7只狗按83.33μg·kg^-1·min^-1静脉滴注60min,在给药期间和停药后不同时间记录ECG及测定血药浓度。C-T数据用药代程序计算药代参数;药效数据用药代-药效同步分析模型计算药效动力学参数,K₁₀, T_1/2,Vd,Cl分别为0.0087min^-1,78.03min,40.55ml·kg^-1和0.421ml·kg^-1·min^-1;K_eO和Ce(50)分别为0.0048min^-1和2.01μg·ml^-1.

PHARMACOKINETIC - PHARMACODYNAMIC ANALYSISOF CHANGROLIN IN DOGS WITH ARRHYTHMIA

The pharrnacokinetics and pharmacodynamics of changrelin (CRL) were studied in 7 dogswith arrhythmia induced by coronary artery ligature. The ECG and the percentage of reduction ratio ofventncular premature were used to evaluate the effect of CRL, and an HPLC method was used to determinethe serurn dnig concentration. A phannacokinetic program was used to fit concentretion-time (C-T) dataand a combined phannatvikinetic-phannacedynamic model was used to analyze effect-time ( E - T) data inindividual dogs. Mfter infusion with CRL 83 . 33 μg.kg^-1.min^-1 for 60 min, it was found that K₁₀, T_1/2,Vd, Cl and Ce were 0.0087 min^-1 , 78.03 min, 40.55 ml.kg^-1 , 0.42 ml.kg^-1. min^-1, and 2.01μg. ml^-1, respectively.