|
|||||
|
|
| 间硝苯地平对血管紧张素Ⅱ促进血管平滑肌细胞增殖和蛋白质合成的影响 | |
| 引用本文： | 古宏标,汤聿海,徐毅. 间硝苯地平对血管紧张素Ⅱ促进血管平滑肌细胞增殖和蛋白质合成的影响[J]. 药学学报, 1996, 31(10): 732-736 |
| 作者姓名： | 古宏标 汤聿海 徐毅 |
| 作者单位： | 广东药学院病理生理教研室 |
| 摘 要： | 以培养血管平滑肌细胞(vascularsmcothmusclecell,VSMC)为模型,观察了间硝苯地平(m-nifedipine,m-Nif)对血管紧张素Ⅱ(angiotensinⅡ,ANGⅡ)促进VSMC增殖和蛋白质合成的影响。结果表明,m-Nif抑制ANGⅡ(100nmol·L-1)引起VSMC[3H]thymidine和[3H]leucine参入,并呈剂量依赖性。m-Nif(2×10-6mol·L-1)可抑制ANGⅡ对VSMC的刺激、DNA及蛋白质合成速率,分别降低了46%,58%,53%。提示m-Nif可抑制ANGⅡ对VSMC增殖和蛋白合成的促进作用。 |
| 关 键 词： | 间硝苯地平 血管紧张素Ⅱ 血管平滑肌细胞 蛋白质合成 |
| 收稿时间： | 1995-11-07 |
INHIBITORY EFFECTS OF M-NIFEDIPINE ON ANGIOTENSIN ⅡSTIMULATED PROLIFERATION AND PROTEIN SYNTHESIS IN CULTURED RABBIT AORTIC SMOOTH MUSCLE CELLS |
|
| HB Gu,YH Tang and Y Xu. INHIBITORY EFFECTS OF M-NIFEDIPINE ON ANGIOTENSIN ⅡSTIMULATED PROLIFERATION AND PROTEIN SYNTHESIS IN CULTURED RABBIT AORTIC SMOOTH MUSCLE CELLS[J]. Acta pharmaceutica Sinica, 1996, 31(10): 732-736 | |
| Authors: | HB Gu YH Tang Y Xu |
| Abstract: | By using rabbit aortic smooth muscle cells(VSMC)in culture as a model,theeffects of m-nifedipine(m-Nif)on the growth of VSMC were observed.The results showed that m-Nif inhibited [3H]-thymidine and[3H]-leucine incorporation into DNA and protein,ecreased cellnumber in a concentration-dependent manner in angiotensinⅡ(ANGⅡ)induced VSMC.At theconcentration of 2 μmol·L-1,m-Nif was found to reduce the ANGⅡ(100 nmol·L-1)stimulated[3H]-thymidine,[3H]-leucine incorporation and cell number by 46%,58% and 53%,respectively。Our results suggest that m-Nif can inhibit ANG Ⅱ stimulated proliferation and protein synthesis incultured rabbit aortic VSMC. |
| Keywords: | Angiotensin Ⅱ Smooth muscle cell Protein synthesis m-Nifedipine |
| 本文献已被 维普 等数据库收录！ | |
| 点击此处可从《药学学报》浏览原始摘要信息 | |
| 点击此处可从《药学学报》下载全文 | |