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| HPV16E749-57及其修饰肽对小鼠肿瘤生长特性和转移规律的影响 | |
| 引用本文： | 徐云升,林治华,郝飞,李秉煦,林霖霖. HPV16E749-57及其修饰肽对小鼠肿瘤生长特性和转移规律的影响[J]. 温州医学院学报, 2006, 36(4): 306-308 |
| 作者姓名： | 徐云升 林治华 郝飞 李秉煦 林霖霖 |
| 作者单位： | 1. 温州医学院第一附属医院,皮肤科,浙江,温州,325000 2. 重庆工学院,生物工程学院,重庆,400050 3. 第三军医大学附属西南医院,皮肤科,重庆,400038 |
| 摘 要： | 目的:探讨人乳头瘤病毒16型E7抗原表位E749-57及其修饰肽是否能够在体诱导特异性细胞毒性T细胞杀伤效应,以及是否具有相应的治疗作用.方法:以HPV16E749-57及其修饰肽免疫荷瘤小鼠,研究小鼠肿瘤的生长特性和转移规律.结果:经修饰肽和原有表位HPV16E749-57免疫的荷瘤小鼠,瘤细胞的转移率显著降低,平均存活时间明显延长.结论:修饰肽具有特异性细胞毒性T细胞诱导活性,并且能够起到一定的治疗作用. |
| 关 键 词： | 乳头瘤病毒,人 肿瘤 表位,T淋巴细胞 |
| 文章编号： | 1000-2138(2006)04-0306-03 |
| 收稿时间： | 2005-12-16 |
| 修稿时间： | 2005-12-16 |
Effect of HPV16E749-57 and the peptide modified from E749-57 on growth behavior and metastatic pattern of tumor in mouse |
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| XU Yun-sheng, LIN Zhi-hua,HAO Fei,et al.. Effect of HPV16E749-57 and the peptide modified from E749-57 on growth behavior and metastatic pattern of tumor in mouse[J]. Journal of Wenzhou Medical College, 2006, 36(4): 306-308 | |
| Authors: | XU Yun-sheng LIN Zhi-hua HAO Fei et al. |
| Affiliation: | Department of Dermatology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000 |
| Abstract: | Objective:To investigate the abilitiy of HPV16E749-57 and the peptide modified from E749-57 to induce the generation of specific cytotoxicity T lymphocyte in vivo, and its therapeutical effect. Methods: the mouse with tumor was immunized with HPV16E749-57 and the peptide modified from E749-57, and growth behavior and metastatic pattern of tumor were studied in mouse. Results:HPV16E749- 57 and the peptide modified from E749-57 had the effect of lowering the metastasis rate and extended the mean survival time. Conclusion:The peptide modified from HPV16E749-57 has the activity of inducing cytolytic t lymphocytes,and the therapeutical effect. |
| Keywords: | Papillomavirus human tumor epitopes T-lymphocyte |
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