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| 壳聚糖包覆的硝酸毛果芸香碱眼用亚微乳的研究 | |
| 引用本文： | Wei J,He HL,Zheng CL,Zhu JB. 壳聚糖包覆的硝酸毛果芸香碱眼用亚微乳的研究[J]. 药学学报, 2011, 46(8): 990-996 |
| 作者姓名： | Wei J He HL Zheng CL Zhu JB |
| 作者单位： | 中国药科大学药物制剂研究所; |
| 摘 要： | 本文设计了一种壳聚糖包覆的硝酸毛果芸香碱眼用亚微乳(chitosan-coated pilocarpine nitrate submicroemulsion,CS-PN/SE),旨在开发一种新型的具有黏膜黏附性的亚微乳眼部给药系统,以延长药物在眼表滞留时间,促进药物的眼部吸收。以中长链甘油三酯(medium chain triglycerides,MCT)为油相,Tween 80为主乳化剂,采用高速剪切工艺制备硝酸毛果芸香碱亚微乳(pilocarpine nitrate submicro emulsion,PN/SE),进一步采用孵育法制备CS-PN/SE,并利用星点设计-效应面优化法进行处方优化。对其粒径、zeta电位、包封率和微观形态进行表征,以新西兰白兔为动物模型,评价了CS-PN/SE在兔眼表滞留特性以及缩瞳作用。眼表滞留特性评价结果显示,与硝酸毛果芸香碱溶液剂组(pilocarpine nitrate solution,PNs)和PN/SE组相比,CS-PN/SE组在眼表的清除率下降,KCS-PN/SE为(0.006 4±0.000 3)min-1,平均驻留时间(mean residence tim... |
| 关 键 词： | 硝酸毛果芸香碱 壳聚糖 黏膜黏附性 眼表滞留特性 缩瞳作用 |
Chitosan-coated ophthalmic submicro emulsion for pilocarpine nitrate |
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| Wei Jun,He Hong-Liang,Zheng Chun-Li,Zhu Jia-Bi. Chitosan-coated ophthalmic submicro emulsion for pilocarpine nitrate[J]. Acta pharmaceutica Sinica, 2011, 46(8): 990-996 | |
| Authors: | Wei Jun He Hong-Liang Zheng Chun-Li Zhu Jia-Bi |
| Affiliation: | WEI Jun,HE Hong-liang,ZHENG Chun-li,ZHU Jia-bi(Pharmaceutical Research Institute,China Pharmaceutical University,Nanjing 210009,China) |
| Abstract: | The study is to design chitosan-coated pilocarpine nitrate submicro emulsion(CS-PN/SE) for the development of a novel mucoadhesive submicro emulsion,aiming to prolong the precorneal retention time and improve the ocular absorption.CS-PN/SE was fabricated in two steps: firstly,pilocarpine nitrate submicro emulsion(PN/SE) was prepared by high-speed shear with medium chain triglycerides(MCT) as oil phase and Tween 80 as the main emulsifier,and then incubated with chitosan(CS) acetic solution.The preparation pr... |
| Keywords: | pilocarpine nitrate chitosan mucoadhesive precorneal retention property miotic effect |
| 本文献已被 CNKI PubMed 等数据库收录！ | |