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| 天然黄酮类化合物及其衍生物的构效关系研究进展 | |
| 引用本文： | Zhong JQ,Li B,Jia Q,Li YM,Zhu WL,Chen KX. 天然黄酮类化合物及其衍生物的构效关系研究进展[J]. 药学学报, 2011, 46(6): 622-630 |
| 作者姓名： | Zhong JQ Li B Jia Q Li YM Zhu WL Chen KX |
| 作者单位： | 上海中医药大学中药学院;中国科学院上海药物研究所药物发现与设计中心; |
| 基金项目： | 国家“重大新药创制”科技重大专项资助项目(2009ZX09311) |
| 摘 要： | 天然黄酮类化合物是广泛分布于自然界的一大类化合物,已有文献报道其具有抗癌、抗氧化、抗炎、保肝、抗血栓形成、舒张血管、抗病毒、抗菌和抗过敏等多种药理活性。但该类化合物因溶解度差、生物利用度不高等自身缺点而限制了临床上的广泛应用。目前国内外许多课题组选择以天然黄酮为研究对象,通过结构改造研究其针对不同生理活性的构效关系,力求克服其自身缺点,开发出一批具有新颖结构的黄酮类药物的先导化合物。本文总结分析了近几年该类化合物构效关系的研究进展,期望为黄酮类衍生物的设计合成提供参考。 |
| 关 键 词： | 黄酮类化合物 衍生物 构效关系 |
Advances in the structure-activity relationship study of natural flavonoids and its derivatives |
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| Zhong Jian-Qing,Li Bo,Jia Qi,Li Yi-Ming,Zhu Wei-Liang,Chen Kai-Xian. Advances in the structure-activity relationship study of natural flavonoids and its derivatives[J]. Acta pharmaceutica Sinica, 2011, 46(6): 622-630 | |
| Authors: | Zhong Jian-Qing Li Bo Jia Qi Li Yi-Ming Zhu Wei-Liang Chen Kai-Xian |
| Affiliation: | ZHONG Jian-qing1,LI Bo2,JIA Qi1,LI Yi-ming1,ZHU Wei-liang2*,CHEN Kai-xian1,2*(1.College of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China,2.Drug Design and Discovery Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,China) |
| Abstract: | Flavonoids are a large class of compounds widely distributed in nature.Many pharmacological activities of flavonoids have been reported such as anti-cancer,antioxidant,anti-inflammatory,hepatoprotective,antithrombotic,vasodilator,antiviral,antibacterial,antiallergic,and so on.In recent years,domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities.As part of the mechanisms ar... |
| Keywords: | flavonoids derivatives structure-activity relationship |
| 本文献已被 CNKI PubMed 等数据库收录！ | |