| 去乙酰化酶SIRT3抗衰老研究进展 |
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| 引用本文： | 郝栋,张力华.去乙酰化酶SIRT3抗衰老研究进展[J].现代医学仪器与应用,2011(3). |
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| 作者姓名： | 郝栋 张力华 |
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| 作者单位： | 华中科技大学同济医学院附属梨园医院老年病科; |
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| 基金项目： | 2011-2022年度湖北省卫生厅科研一般项目(JX5B55) |
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| 摘 要： | 去乙酰化酶Sirtuin是一个在低等动物中被广泛研究的抗衰老蛋白因子。哺乳动物的同源蛋白家族SIRT3蛋白通过抗氧化机制防御氧自由基氧化应激介导的机体损伤,在抗衰老过程中发挥着重要作用。能量限制可通过增加SIRT3活性来延长寿命,SIRT3作为抗衰老和治疗衰老相关疾病的靶点正在成为研究热点。本文就SIRT3抗衰老的研究进展做一总结。
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| 关 键 词： | SIRT3 抗衰老 活性氧自由基 能量限制 |
Research progression of deacetylase SIRT3 on antiaging |
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| Authors: | HAO Dong ZHANG Lihua |
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| Institution: | HAO Dong,ZHANG Lihua (Department of Geriatrics,Liyuan Hospital of Tongji Medical College,Huazhong University of Science and Technology,Hubei,Wuhan 430077,China) |
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| Abstract: | The silent information regulator protein 2(Sir2)is a widely-studied antiaging protein factor in the lower animals. SIRT3, a mammalian Sir2 homologue, defense oxidative stress damage mediated by oxygen free radicals through antioxidant mechanism in the aging process. Calorie restriction may prolong the life expectancies in these animals by SIRT3-mediated deacetylase activity. Therefore, SIRT3 may be seen as a new therapy target for many age-related diseases and antiaging. In this paper, we summarize the rece... |
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| Keywords: | SIRT3 Antiaging Reactive oxygen species (ROS) Calorie restriction |
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