| 多药耐药相关蛋白及其在肿瘤耐药中的作用 |
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| 作者姓名： | Zhang H Fu LW |
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| 作者单位： | 中山大学肿瘤防治中心华南肿瘤学国家重点实验室; |
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| 基金项目： | 国家自然科学基金资助项目(81072669) |
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| 摘 要： | 多药耐药(multidrug resistance,MDR)是导致肿瘤患者化疗失败的主要原因。介导多药耐药的重要机制之一是多药耐药相关蛋白(multidrug resistance-associated proteins,MRPs)的表达增加。MRPs是一类ATP能量依赖型跨膜转运蛋白,是具有选择性和特异性的药物外排泵。本文主要针对MRPs的生理特征、结构特点、耐药谱特征及其逆转进行综述。
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| 关 键 词： | 肿瘤 多药耐药 多药耐药相关蛋白 药物外排泵 逆转 |
Multidrug resistance-associated proteins and their roles in multidrug resistance |
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| Zhang H,Fu LW.Multidrug resistance-associated proteins and their roles in multidrug resistance[J].Acta Pharmaceutica Sinica,2011,46(5):479-486. |
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| Authors: | Zhang Hui Fu Li-wu |
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| Institution: | ZHANG Hui,FU Li-wu(State Key Laboratory of Oncology in South China,Cancer Center,Sun Yat-sen University,Guangzhou 510060,China) |
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| Abstract: | Multidrug resistance(MDR) is a major impediment to the success of cancer chemotherapy.Multidrug resistance-associated proteins(MRPs) play an important role in the process of MDR.As an ATP-binding cassette(ABC) transporter superfamily,MRPs are selective and specific drug efflux pumps.In this paper,physiological characteristics,structural characteristics and resistance profile of MRPs and the associated reversal studies are reviewed. |
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| Keywords: | tumor multidrug resistance multidrug resistance-associated protein drug efflux pump reverse |
| 本文献已被 CNKI PubMed 等数据库收录！ |
