超声检查对大肠肿瘤早期诊断病理基础与临床应用系列研究──基础实验

①用二甲肼诱发大鼠结直肠肿瘤３３个，水槽内７．５ＭＨｚ超声检出最小病灶２～３ｍｍ，浸润粘膜层的息肉样良性病变２１．２％，粘膜下层早癌３６．４％，肌层浆膜层中晚期癌４５．５％，肿瘤生物学行为超声图像特征与病理诊断符合率９６．９％。位于粘膜层的原位癌，粘膜肌层的早癌超声无法辩认。病理所见腺癌为主与人类肠癌相似，故鼠肠癌大体所见超声图像及病理为肠癌早期诊断提供超声病理基础。超声对胃肠肿瘤标本的超声分期正率达８６．４％。②用自行研制大肠超声显像液灌注（ＵＢＣＥ）为腹部Ｂ超检查提供良好声窗，图像清晰，增强病人对大剂量保留灌肠的适应力，经Ｘ线气钡双重造影，纤维肠镜手术病理验证ＵＢＣＥ超声检查诊断大肠肿瘤是安全、实用的好方法。

Serial Studies on Pathological Basis and Clinical Application of Diagnosis of Large Bowel Tumour by Ultrasonography-Basis and Experimental Study

Thirty three colorectal tumors were induced by dimethylhydrazine (DMH) in white rats,The smallest lesion examined by US with high frequency transducer in the water was 2-3mm. The Coincidence rate of ultrasonic diagnosis with pathological diagnosis was 96. 9%. But there was no difference between carcinoma in situ and in muscular layer of mucosa by US. Adnocarcinomas . and their histopathological characteristic of white rats were similar to those of human large bowel tumor. This experimental study provided the ultrasonic and pathological basis to diagnose early colorectal cancers in clinic. The accuracy rate of the gastrointestinal cancer specimens staging by US was 86. 4%. Verified by barium enema and airbarium double contrast radiography or fibercoloscoty, abdominal US was a valuable and safe method for diagnosing during UBCE.