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| 萘普生控释片的处方筛选 | |
| 引用本文： | 杨红 李成蓉. 萘普生控释片的处方筛选[J]. 中国医药工业杂志, 1997, 28(5): 214-217 |
| 作者姓名： | 杨红 李成蓉 |
| 作者单位： | 华西医科大学 |
| 摘 要： | 筛选了１４个萘普生控释片处方。其中处方１４，２ｈ累积释放药物１８．０％，６ｈ为４８．６％，１２ｈ为９４．０％，释放速率接近零级动力学，释放速率常数ｋ为０．０７７６ｈ－１，释放ｔ１／２为６ｈ。 |
| 关 键 词： | 萘普生 控释片 释放度 |
FORMULATION SCREENING OF NAPROXEN CONTROLLED RELEASE TABLETS |
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| YANG Hong ,LI Cheng Rong DENG An Ping,LI Ying,LIU Qiong Fang. FORMULATION SCREENING OF NAPROXEN CONTROLLED RELEASE TABLETS[J]. , 1997, 28(5): 214-217 | |
| Authors: | YANG Hong LI Cheng Rong DENG An Ping LI Ying LIU Qiong Fang |
| Affiliation: | YANG Hong *,LI Cheng Rong DENG An Ping,LI Ying,LIU Qiong Fang |
| Abstract: | Among 14 formulations designed, the 14th was the best one:18.0% of naproxen was released in 2 h, 48.6% in 6 h, and 94.0% in 12 h. Its releasing rate in vitro was found to be in accordance with zero order kinetics, and the release rate constant k in vitro was 0.0776 h -1 and t 1/2 of release 6 h. |
| Keywords: | naproxen controlled release tablet releasing rate |
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