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Strategies in the treatment of diffuse pontine gliomas: the therapeutic role of hyperfractionated radiotherapy and chemotherapy
Authors:Mark T. Jennings  Michael L. Freeman  Michael J. Murray
Affiliation:(1) Departments of Neurology and Radiation Oncology, Vanderbilt School of Medicine, Nashville, TN, USA;(2) Department of Neurology, Vanderbilt School of Medicine, 2100 Pierce Ave., 37232-3375 Nashville, TN, USA
Abstract:
This article will review the current treatment of pediatric patients with diffuse pontine gliomas (DPG) and discuss three potential avenues of therapeutic research including (i) radiotherapy (RT) in combination with radiation sensitizers, (ii) dose-intensive, induction chemotherapy with hematopoietic support followed in sequence with RT applied as a lsquoconsolidationrsquo therapy, and (iii) the interleafed application of phase-specific chemotherapeutic agents and hyperfractionated external beam radiotherapy (HFEBRT) referred to as lsquochemoradiotherapyrsquo.
Keywords:brainstem gliomas  hyperfractionated radiotherapy  chemoradiotherapy  peripheral stem cell harvesting  radio sensitizers
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