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A metastatic colon cancer model using nonoperative transanal rectal injection |
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| Authors: | Melissa Donigan Bryan D. Loh Laurie S. Norcross Shuan Li Paul R. Williamson Samuel DeJesus Andrea Ferrara Joseph T. Gallagher Cheryl H. Baker |
| Affiliation: | (1) Cancer Research Institute of M. D. Anderson Cancer Center Orlando, 110 Bonnie Loch Court, Orlando, FL 32806, USA;(2) Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA;(3) Colon and Rectal Clinic, Orlando, FL, USA;(4) Orlando Regional Medical Center, Orlando, FL, USA; |
| Abstract: | BackgroundThis study aimed to develop a noninvasive orthotopic model for metastasis of colon and rectal cancer using a transanal approach. Currently, the most accurate orthotopic representation of metastatic human colon cancer is via a cecal injection. The transanal model allows for further examination of systemic immune responses, tumor take, and onset of metastasis without prior surgical intervention. |
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