新生儿缺氧缺血性脑病研究进展

新生儿缺氧缺血性脑病(HIE)发生机制关键是二次能量衰竭,目前,人们利用电生理学、细胞生理学和影像学等手段寻找能量衰竭过程中的特征性标志物,为其诊断、预后提供依据.HIE临床治疗方法多样,其中,亚低温治疗应注意治疗时问窗的选择,而高压氧、神经保护剂、神经干细胞移植等疗效尚需进一步的临床验证.

Progress in neonate with hypoxic-ischemic encephalopathy

The key mechanism of hypoxic-ischemic encephalopathy(HIE) is two-times energy exhaustion.Recently, electrophysiology, cell physiology and imageology are performed to figure out some new biomarkers for clinical diagnosis and prognosis. And now, there are different therapies for HIE. For Sub-low temperature therapy,selecting appropriate time of therapy window is more important, and the therapeutic effects of other therapies,hyperbaric oxygenation, neuroprotectants, neural stem cell transplantation etc, need to be validated clinically.