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| 洋紫荆中生物碱类抗肿瘤活性成分的研究 | |
| 引用本文： | 赵燕燕,崔承彬,蔡兵,韩冰,孙启时.洋紫荆中生物碱类抗肿瘤活性成分的研究[J].中国药物化学杂志,2004,14(3):169-171. |
| 作者姓名： | 赵燕燕 崔承彬 蔡兵 韩冰 孙启时 |
| 作者单位： | 1. 沈阳药科大学中药学院,辽宁,沈阳,110016;天津生物医药研究所,天津,300384 2. 中国海洋大学海洋药物与食品研究所，山东，青岛，266003；军事医学科学院毒物药物研究所，北京，100850 3. 天津生物医药研究所,天津,300384 4. 沈阳药科大学中药学院,辽宁,沈阳,110016 |
| 摘 要： | 目的研究洋紫荆中的抗癌活性成分.方法采用色谱法与生物活性追踪相结合分离纯化活性成分.丽丝胺罗丹明B(SRB)法检测化合物对K562细胞增殖的影响,流式细胞仪检测化合物对K562细胞周期的影响.结果分离得到4个具有活性的生物碱类化合物,用现代谱学方法鉴定为N-naphthyl-2-aniline(1)、biocyclomahanimbine(2)、mahanimbine(3)、girinimbine(4).化合物1～3体外具有明显诱导K562细胞调亡作用.结论 4个生物碱类化合物均为该属中首次分离,其中化合物1的体外抗癌活性为首次报道. |
| 关 键 词： | 药物化学 分离 鉴定 色谱法 抗癌活性 羊蹄甲属 生物碱 |
| 文章编号： | 1005-0108(2004)03-0169-03 |
Study on the constituents with anticanceractivities of alkaloids from Bauhimia variegata L. |
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| ZHAO Yan-yan.Study on the constituents with anticanceractivities of alkaloids from Bauhimia variegata L.[J].Chinese Journal of Medicinal Chemistry,2004,14(3):169-171. | |
| Authors: | ZHAO Yan-yan |
| Institution: | ZHAO Yan-yan~ |
| Abstract: | Aim To study the anticancer constituents from Bauhimia variegata L.Methods The compounds were isolated through a bioassay-guided separation procedure and identified by spectroscopic analysis.The cell proliferation inhibitory and apoptosis inducing activities were assayed using K562 cells by the SRB method and flow cytometry respectively.Result Four alkaloids were isolated and identified as N-naphthyl-2-aniline,biocyclomahanimbine,mahanimbine,girinimbine.Conclusion The four compounds were obtained from this genus for the first time and the apoptosis inducing activities of N-naphthyl-2-aniline had never been reported before. |
| Keywords: | medicinal chemistry isolation identificantion chromatography anticancer activity Bauhimia alkaloid |
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