A comparative study of the effects of cinnarizine, sulpiride and thiethylperazine on vestibular nystagmus in rabbits |
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| Authors: | W J Oosterveld |
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| Affiliation: | Vestibular Department, E.N.T Clinic, Wilhelmina Gasthuis, University of Amsterdam, The Netherlands |
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| Abstract: | ![]()
The effects of cinnarizine, sulpiride, thiethylperazine and a placebo on vestibular nystagmus in rabbits were investigated. The nystagmus was provoked by means of a torsion swing. A suppressive effect was shown by all drugs and not by the placebo. A fast and strong effect was seen after the administration of sulpiride, however this effect decreased after 1 h. The onset of the effect of cinnarizine was slower but the effect lasted longer. Thiethylperazine had a clear suppressive effect but less strong and shorter than that of the other two drugs. |
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| Keywords: | Nystagmus suppression Vestibular system Cinnarizine Sulpiride Thiethylperazine |
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