凝血因子在结直肠癌中的表达及相关性的研究

目的 研究结肠癌患者血浆中凝血因子D-二聚体和纤溶酶原激活物抑制剂-1（PAI-1）的变化及其临床意义.方法 选择结直肠癌患者74例为实验组,其中37例施行传统开腹手术（open resection,OR）,37例施行腹腔镜下手术（laparoscop-ic resection,LR）,于手术前后采血并检测血浆D-二聚体和PAI-1浓度,良性病患者37例为对照组,同时实验组内患者按照Dukes分期标准分为AB、CD两期,并对各组间D-二聚体水平进行比较和统计分析.结果 两实验亚组结直肠癌患者的D-二聚体和PAI-1水平非常显著高于对照组（P＜0.01）.在结直肠癌患者的Dukes分期检测中,DukesCD期患者的D-二聚体和PAI-1水平明显高于AB期（P＜0.05）.结论 结直肠癌患者血液的高凝状态是其重要病机特征,D-二聚体和PAI-1的检测对结直肠癌的分期及预后有一定的指导意义.

Studys on correclation of clotting factor in diagnosis and treatment of colorectal carcinoma

Objective Toinvestigate the changes and significance of the serum of D-dimer and plasminogen activator inhibitor-1 （PAI-1） in patients with colon cancer.Methods 74 cases of colorectal cancer patients in the experimental group within which 37 patients were underwent conventional open surgery （open resection,OR） and the other half were underwent laparoscopic surgery （laparoscopic resection,LR）.Serum Ddimer and PAI-1 concentration were monitored before and after surgery.37 benign patients were selecteded in the control group.At the same time,the patients in the experimental group in accordance with the Dukes staging is divided into two AB,CD,and among the groups D-dimer levels were compared.Results Two experimental subgroups of colorectal cancer patients with D-dimer and PAI-1 level was significant higher than that in the control group （P ＜0.01）.In the Dukes stage detection of colorectal cancer patients,the patients with DukesCD of D-dimer and PAI-1 levels were significantly higher than that of AB （P ＜0.05）.Conclusion The ancer patients blood hypercoagulable state is important disease characteristics while D-dimer and PAI-1 detection is significantly important to colorectal cancer staging and prognosis.