Puerarin protects brain tissue against cerebral ischemia/reperfusion injury by inhibiting the inflammatory response |
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| Authors: | Feng Zhou, Liang Wang, Panpan Liu, Weiwei Hu, Xiangdong Zhu, Hong Shen, Yuanyuan Yao |
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| Affiliation: | [1]Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China; [2]Medical College, Ningbo University, Ningbo, Zhejiang Province, China; [3]Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China |
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| Abstract: | ![]()
Puerarin, a traditional Chinese medicine, exerts a powerful neuroprotective effect in cerebral ischemia/reperfusion injury, but its mechanism is unknown. Here, we established rat models of middle cerebral artery ischemia/reperfusion injury using the suture method. Puerarin (100 mg/kg) was administered intraperitoneally 30 minutes before middle cerebral artery occlusion and 8 hours after reperfusion. Twenty-four hours after reperfusion, we found that puerarin significantly improved neurological deficit, reduced infarct size and brain water content, and notably diminished the expression of Toll-like receptor-4, myeloid differentiation factor 88, nuclear factor kappa B and tumor necrosis factor-α in the ischemic region. These data indicate that puerarin exerts an anti-inflammatory protective effect on brain tissue with ischemia/reperfusion damage by downregulating the expression of multiple inflammatory factors. |
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| Keywords: | nerve regeneration brain injury puerarin cerebral ischemia reperfusion injury rats inflammatory reaction Toll-like receptor-4 nuclear factor kappa B myeloid differentiation factor 88 tumor necrosis factor-α middle cerebral artery occlusion neural regeneration |
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