Quantitative analysis by reversed-phase high-performance liquid chromatography and retinal neuroprotection after topical administration of moxonidine

AIM: To describe the referral patterns of children with primary or secondary childhood glaucoma and their presenting symptoms in Northern Tanzania.METHODS: A retrospective observational study of children <17y with primary (PCG) or secondary childhood glaucoma (SCG) who were referred to KCMC eye department between 2000 and 2013 was conducted. Presenting symptoms, age at presentation, place of origin, distance to hospital, type of glaucoma, visual acuity, optic disc appearance (vertical cup-to-disc ratio) and type of referral were described.RESULTS: Seventy patients with PCG and 27 patients with SCG were included in the study. Median age at first presentation was 1 year in the PCG group (range 0-16) and 9 years in the SCG group (range 1-5y). In both groups around 87% of the children presented already with low vision (logMAR>.48). Most of the children (60%) and their caretakers presented on their own initiative, while 24% were sent by different general health cadres and 13% by eye care professionals. Buphthalmos was the main symptom mentioned as a trigger for presentation.CONCLUSION: The study shows that most of the children presented late resulting in advanced stages of glaucoma at the time of initiation of treatment. The majority attended the referral eye department on their own initiative with buphthalmos being the most commonly described symptom. Awareness creation among caretakers of children followed by general health care and eye care providers may help to increase and accelerate referrals.