|
|||||
|
|
| SOCS3及Eotaxin-2在变应性鼻炎中的表达及意义 | |
| 引用本文： | 王新龙,赵建东. SOCS3及Eotaxin-2在变应性鼻炎中的表达及意义[J]. 山东医大基础医学院学报, 2010, 0(2) |
| 作者姓名： | 王新龙 赵建东 |
| 作者单位： | 山东大学医学院;山东大学第二医院耳鼻咽喉科; |
| 摘 要： | 目的研究SOCS3及Eotaxin-2在变态反应性鼻炎(AR)鼻黏膜中的表达及其相互关系和临床意义。方法取20例AR患者(AR组)和15例单纯鼻中隔偏曲患者(对照组)鼻黏膜为研究对象,应用免疫组织化学技术分别检测SOCS3及Eotaxin-2的表达,并分析SOCS3及Eotaxin-2表达的相关性。结果在AR患者鼻黏膜中,SOCS3及Eotaxin-2的表达上调,在鼻黏膜炎性细胞、上皮细胞、腺体细胞、血管内皮细胞均呈显著性表达。SOCS3的平均光密度值为0.2401±0.01463,Eotaxin-2为0.2398±0.01423,与对照组相比,差异均有统计学意义(P均<0.01)。AR患者鼻黏膜中SOCS3及Eotaxin-2的表达具有相关性(r(0.951,P<0.01)。结论AR患者SOCS3及Eotaxin-2在鼻黏膜组织中表达增高,且二者呈正相关。 |
| 关 键 词： | 鼻炎 变应性 细胞因子信号转导抑制因子3 Eotaxin-2 |
Expressions of SOCS3 and Eotaxin-2 in allergic rhinitis |
|
| WANG Xin-long,ZHAO Jian-dong. Expressions of SOCS3 and Eotaxin-2 in allergic rhinitis[J]. Journal of Preclinical Medicine College of Shandong Medical University, 2010, 0(2) | |
| Authors: | WANG Xin-long ZHAO Jian-dong |
| Affiliation: | WANG Xin-long1,ZHAO Jian-dong2(1. School of Medicine,Sh,ong University,Jinan 250012,China,2.Department of Otolaryngology,Second Affiliated Hospital,Jinan 250033,China) |
| Abstract: | Objective To investigate expressions of SOCS3 and Eotaxin-2 in allergic rhinitis(AR).Methods Twenty cases of allergic rhinitis nasal mucosa tissues served as the experimental group and fifteen cases of deflection of nasal septum nasal mucosa tissues as the control group.Immunohistochemisty was used to detect expressions of SOCS3 and Eotaxin-2.The relationship between SOCS3 and Eotaxin-2 expressions was analyzed.Results SOCS3 and Eotaxin-2 expressions were increased in AR patients.There was positive staining... |
| Keywords: | Rhinitis allergic Suppressor of cytokine singnaling-3 Eotaxin-2 |
| 本文献已被 CNKI 等数据库收录！ | |