| 大肠癌细胞的药敏试验结果分析及临床意义 |
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| 引用本文： | 姚清深,俸小平,秦军,覃运荣,周林荣,陈春媚,覃欣. 大肠癌细胞的药敏试验结果分析及临床意义[J]. 肿瘤基础与临床, 2007, 20(2): 169-170 |
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| 作者姓名： | 姚清深 俸小平 秦军 覃运荣 周林荣 陈春媚 覃欣 |
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| 作者单位： | 玉林市红十字会医院普外二科,广西,玉林,537000;玉林市红十字会医院普外二科,广西,玉林,537000;玉林市红十字会医院普外二科,广西,玉林,537000;玉林市红十字会医院普外二科,广西,玉林,537000;玉林市红十字会医院普外二科,广西,玉林,537000;玉林市红十字会医院普外二科,广西,玉林,537000;玉林市红十字会医院普外二科,广西,玉林,537000 |
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| 摘 要： | 目的通过测定大肠癌患者对5-氟脲嘧啶（5-Fu）、顺铂（DDP）、阿霉素（ADM）、丝裂霉素（MMC）、奥沙利伯（OXA）及联用化疗药物的体外敏感性试验，探讨肿瘤药敏试验对大肠癌个体化疗的应用价值。方法采用组织块培养-终点染色-计算机图像分析法（TECIA）。结果36例大肠癌细胞对试验化疗药物的敏感性由高到低依次为OXA、F＋M（5-Fu＋MMC）、F＋D（5-Fu＋DDP）及DDP、5-Fu、O＋F（5-Fu＋OXA）、MMC、ADM。结论TECIA法的体外肿瘤药敏试验在大肠癌的l临床用药及个体化化疗方面具有重要的指导意义。
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| 关 键 词： | 肿瘤药敏试验 大肠癌 TECIA法 个体化化疗 |
| 文章编号： | 1673-5412(2007)02-0169-02 |
| 修稿时间： | 2006-08-24 |
Analysis of Extracorporeal Cancer Sensitive Results and Clinical Meaning in Cases with Large Intestine Carcinoma |
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| Yao Qingshen,Feng Xiaoping,Qin Jun,Qin Yunrong,Zhou Linrong,Chen Chunmei,Qin Xin. Analysis of Extracorporeal Cancer Sensitive Results and Clinical Meaning in Cases with Large Intestine Carcinoma[J]. Journal of Basic and Clinical Oncology, 2007, 20(2): 169-170 |
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| Authors: | Yao Qingshen Feng Xiaoping Qin Jun Qin Yunrong Zhou Linrong Chen Chunmei Qin Xin |
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| Abstract: | Objective We have collected tissues from the cases with large intestine carcinoma,then tested their sensitivities to drugs of 5-fluorouracil(5-Fu), cisplatin(DDP),adriamycin(ADM),mitomycinc(MMC),oxaliplatin(OXA) and combined with chemotherapy to evaluate the effects of drugs sensitivity experiment of cancer in clinical individual chemotherapy of large intestine carcinoma.Methods We tested it by TECIA assay.Results The average inhibiting rates of 36 cases with large intestine carcinoma tissues from high to low were OXA,F M(5-Fu MMC),F D(5-Fu DDP),DDP,5-Fu,O F(5-Fu OXA),MMC and ADM.Conclusions Extracorporeal drug sensitive test has important guidance value for clinical medicine application individual chemotherapy of large intestine carcinoma. |
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| Keywords: | large intestine carcinoma drug sensitive experiment of cancer TECIA assay individual chemotherapy |
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